spring2010npb_101l-final_review_handout

spring2010npb_101l-final_review_handout - NPB 101L Final...

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NPB 101L Final Review Spring 2009 Section 12 Keri Hayakawa
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Lab 1 Introductory Lab Calculations of amplitude and frequency Effects of increasing stimulus voltage, duration and frequency
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Lab 2 Properties of Skeletal Muscle Physiology 1. Contractile force production, sarcomere structure and function, isometric and isotonic contractions 2. Mechanisms behind excitation-contraction coupling, synaptic transmission, sliding filament theory 3. Motor unit recruitment, Henneman Size Principle 4. Temporal summation, tetany 5. Competitive inhibition
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Experiments : Stimulated the __________ nerve to induce the contraction of the __________________ muscle in frog Part 1: Effect of an increase in stimulus INTENSITY Increase in stimulus voltage caused an __________ in muscle tension
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WHY? Increasing stimulus intensity will RECRUIT more MOTOR UNITS and therefore activate more α -motor neurons to cause contraction In lab larger α -MNs recruited first because they have a lower resistance to direct stimulation (opposite Henneman size principle)
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Part 2: Effect of an increase in stimulus FREQUENCY Increase in stimulus frequency will cause an __________ in muscle tension WHY? TEMPORAL SUMMATION Able to fire many APs during a single contraction Muscle fibers not able to fully relax and tensions sum together APs cause an increase of [Ca] in the cytosol allowing for the longer duration of cross-bridge cycling
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Part 3: Effect of Tubocurare Tubocurare will ___________________ tension when stimulating the sciatic nerve WHY? Tubocurare is a competitive inhibitor of the nAChR (it competes with ACh for receptor binding site) Opening of the nAChR is necessary for the depolarization of the muscle cell No depolarization -> no increase in Calcium -> no contraction
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Part 4: Effect of Direct Stimulation After tubocurare direct stimulation of the muscle will elicit contractions WHY? By directly causing the depolarization of the muscle cell we bypass the need for the opening of the nAChR
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Ca 2+ ACh Na + K + SR SR SR SR SR SR SR SR Depolarization causes voltage gated Ca channels to open -> influx of calcium triggers synaptic vesicles to fuse with membrane and release ACh -> ACh will bind to nAChR -> causes an influx of Na which depolarizes the muscle fiber-> action potential propagated along T-tubules -> voltage gated Ca channels on T-tubules open -> causes opening of Ca channels on the SR -> increase in intracellular Ca -> Ca binds to troponin C -> conformational change moves tropomyosin from mysosin binding site on actin -> Myosin binds actin -> cross-bridge cycling -> contraction Ca 2+ ACh Skeletal Muscle Contraction
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Lab 3 Human Reflexes Physiology 1. Components of the Reflex Arc 2. H-Reflex (H-wave, M-wave), motor neurons, Renshaw Cells, antidromic and orthodromic action potentials, refractory period 3. Vestibulo-ocular reflex, vestibular system, hair cells, nystagmus 4. Monosynaptic vs polysynaptic reflexes
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This note was uploaded on 02/07/2011 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Spring '08 term at UC Davis.

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spring2010npb_101l-final_review_handout - NPB 101L Final...

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