lecture 1

lecture 1 - Biochemical Energetics and Metabolism...

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1 Biochemical Energetics and Metabolism (Chem/Biochem 114B)
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2 Course Details Website http://webct.ucsd.edu Office Hours Fri., 5:00-6:00 PM, 4254 Urey Hall Exams Mid-term (in class, 35%), Fri., Feb. 4 Final (65%) ,Fri., Mar. 18 NO make up exams Problem sets Gone over in sections TA’s Joel Grondek, jgrondek@ucsd.edu Anh Nguyen, atn034@ucsd.edu
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3 Outline Text —Biochemistry (6th Edition). Berg, Tymoczko and Stryer, W. H. Freeman and Company, New York. 2006. Topic Time Carbohydrates Weeks 1-2 Citric Acid Cycle, Oxidative Phosphorylation, Photosynthesis, Calvin Cycle Weeks 2-5 Glycogen, Fatty Acids Weeks 6-7 Proteins Weeks 7-8 Nucleotides, Lipids Week 9-10 Metabolic control Weeks 10 Midterm (35%) Final (65%) • Problems from the textbook — gone over in section the following week
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4 Syllabus
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5 How to take notes Lectures are guided tour of detailed information in the textbook Overall important points from Lecture Details from the textbook reading Lecture powerpoints available before the class
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6 Why study metabolism? Metabolism is essential to life Metabolic Disorders lead to diseases Obesity and diabetes Aging (caloric restriction)
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7 Prevalence of Obesity among U.S. Adults, BRFSS, 1985 <10% 10-15% >15%
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8 <10% 10-15% >15% Prevalence of Obesity among U.S. Adults, BRFSS, 1998
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9 1.1 million people died of diabetes in 2005 (WHO) 50% increase expected over next 10 years Childhood obesity ‘Metabolic syndrome’ Cardiovascular disease Insulin resistance Hypertension Growing Plague of Obesity and type II diabetes
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10 Caloric restriction and ageing
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11 Left: adequate nutrition (weight 180lb; BMI 26.0 kg/m 2 ) Right: 7 years of dietary restriction (weight 134lb; BMI 19.4 kg/m 2 ) Caloric restriction and ageing
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Reactions are coupled
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http://www.genome.jp/kegg/metabolism.html Enzyme Commission (EC) number Mapping metabolic pathways
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lecture 1 - Biochemical Energetics and Metabolism...

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