L18 - Monday,November8,2010 ProteinTransportAcrossMembranes...

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Protein Transport Across Membranes Reading: Chapter 15, pages 495 - 509  Objectives We've seen that  1. Compartments are bounded by membranes.  2. Different compartments contain distinct sets of proteins:  o soluble proteins o membrane-associated proteins Organelles  are intracellular membrane-bounded compartments with specialized  functions.  The  primary sequence  of a protein contains two types of information.  o Folding information      is inherent in the chemistry of the amino acid  sequence. After synthesis, a protein spontaneously folds into its active  three-dimensional configuration. o Sorting information      is stored as coded signals in the polypeptide sequence.  These signals are decoded by specialized sorting machines in the cell. The sorting problem in eukaryotic cells:  o Ribosomes are in the cytosol, so that's where protein synthesis occurs. o Many cellular proteins are located in organelles such as mitochondria and  the endoplasmic reticulum. Moreover, mitochondria have four internal  compartments: the matrix, the intermembrane space, the inner membrane  and the outer membrane. Although mitochondria contain their own DNA and ribosomes, most  mitochondrial proteins are synthesized in the cytosol and then  imported . o
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L18 - Monday,November8,2010 ProteinTransportAcrossMembranes...

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