L20 - Friday,November12,2010 Reading Chapter15,pages510514...

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Friday, November 12, 2010 Protein Sorting and Vesicular Transport Reading: Chapter 15, pages 510-514  Objectives Vesicle formation and protein sorting are mechanistically linked.  o Example: at the exit face of the Golgi, secreted proteins are separated from  lysosomal enzymes by being packaged into different types of transport  vesicles. Protein sorting involves selective packaging into vesicles.   o Different kinds of vesicles can be formed. o Each kind of vesicle incorporates one specific class of cargo molecules (e.g.,  lysosomal enzymes vs. secreted proteins). Vesicles form through the action of cytosolic  coat proteins o Initial invagination = "coated pit" o Completed vesicle = "coated vesicle" o Coat proteins are membrane associated, but they are not integrated into  the phospholipid bilayer. The coats on endocytic coated vesicles form a regular polyhedral lattice,  composed of hexagons and pentagons.  These coats are composed of a peripheral membrane protein called  clathrin.   o A clathrin molecule is long and skinny, with a kink in the middle; it  resembles a bent leg. o
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L20 - Friday,November12,2010 Reading Chapter15,pages510514...

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