L20 - Friday,November12,2010...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Friday, November 12, 2010 Protein Sorting and Vesicular Transport Reading: Chapter 15, pages 510-514  Objectives Vesicle formation and protein sorting are mechanistically linked.  o Example: at the exit face of the Golgi, secreted proteins are separated from  lysosomal enzymes by being packaged into different types of transport  vesicles. Protein sorting involves selective packaging into vesicles.   o Different kinds of vesicles can be formed. o Each kind of vesicle incorporates one specific class of cargo molecules (e.g.,  lysosomal enzymes vs. secreted proteins). Vesicles form through the action of cytosolic  coat proteins o Initial invagination = "coated pit" o Completed vesicle = "coated vesicle" o Coat proteins are membrane associated, but they are not integrated into  the phospholipid bilayer. The coats on endocytic coated vesicles form a regular polyhedral lattice,  composed of hexagons and pentagons.  These coats are composed of a peripheral membrane protein called  clathrin.   o A clathrin molecule is long and skinny, with a kink in the middle; it  resembles a bent leg. o
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

L20 - Friday,November12,2010...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online