L09ap - Evidence for an Alternative Glycolytic Pathway in...

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2/10/11 NAD+ + H2O E NADH + ½ O2 & GW= 52.7 kcal/mole ADP + Pi K ATP + H2O ±G. = 7.3 kcal/mole glucose + O2 ± 2 pyruvate + 2 H2O ·G w= -140 kcal/mole Glucose + 2 NAD+ + 2 ADP + 2 Pi y 2 pyruvate + 2 NADH + 2 ATP + 4 H2O 2GZ = -20 kcal/mole
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2/10/11 Anapleurotic anabolic pathways
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2/10/11 Why so many steps? Store energy from carbon oxidation in ATP and NADH Generate modified carbon skeletons as substrates for anabolic pathways Reactions must be mechanistically feasible Maximize energy conservation in coupled reactions Minimize –ΔH at active enzyme Roles of glycolysis
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2/10/11
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Unformatted text preview: Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells Matthew G. Vander Heiden (and 10 others) 17 SEPTEMBER 2010 VOL 329 SCIENCE 1924 Otto Warburg cancer cells consume more glucose than is readily explained by the conventional glycolytic pathway. 2/10/11 Picture 3 Picture 5 Picture 4 Phosphodiester linkage Picture 9 2/10/11 The real struct 2/10/11 Proteins recognize DNA sequences by binding to base edges 2/10/11 Eeukaryotic genomes are much larger than bacterial genomes 2/10/11 Chromatin packing 2/10/11 2/10/11 Nucleosome structure...
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This note was uploaded on 02/09/2011 for the course BIOS 20182 taught by Professor Lahn during the Spring '11 term at UChicago.

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L09ap - Evidence for an Alternative Glycolytic Pathway in...

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