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L11ap - strand as template and another transcribed from the...

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2/10/11 One model for coordinated chain extension
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2/10/11 Dealing with Unwinding
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2/10/11
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2/10/11 E. coli genome – 4.7x106 base pairs Replicates in 60 min 1300 base pairs/s What is the turnover number for DNA polymerase? A. 2600 bases/s B. 1300 bases/s C. 650 bases/s How many strand breaks are made and rejoined by DNA gyrase/s? A. 2600 breaks/s B. 1300 breaks/s C. 650 breaks/s Jet engine at idle: 217 rps; peak is 10x
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2/10/11 Proofreading is essential E. coli replicase makes one error per 104 bases – one per 108 after proofreading
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2/10/11 Replication Initiation
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2/10/11 Termination for circular DNA requires
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2/10/11 Eeukaryotic genomes are much larger than bacterial genomes
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2/10/11 Multiple Origins in Eukaryotes
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2/10/11 Coordination of multiple origins
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2/10/11 Telomerase solves the end-replication problem
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2/10/11 Central Dogma A = Crick B = Watson C = Can’t tell Which DNA strand is the template for making this RNA molecule?
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2/10/11 Consider an RNA molecule produced by transcribing a region of DNA using the Watson
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Unformatted text preview: strand as template and another transcribed from the same region of DNA using the Crick A. Yes B. No 2/10/11 One strand is used as template Not all of the DNA is transcribed This pattern requires directional start signals and stop signals 2/10/11 The Promoter picks the strand The Terminator stops transcription 2/10/11 Chain extension in transcription 2/10/11 The RNA Polymerase in action 2/10/11 Bacterial Transcription Summary 2/10/11 2/10/11 Some Eukaryotic differences 2/10/11 2/10/11 A very big difference 2/10/11 A typical human gene region 2/10/11 Intron-Exon junctions 2/10/11 The splicosome is a ribozyme 2/10/11 Summary Transcript processing into mRNA in eukaryotes 2/10/11 Coupled transcription and splicing A B C D Where is the gene promoter? A B C D Where is the 5’ end of the anti-sense (template) strand? 2/10/11 mRNA export from the nucleus...
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