L0710ap - committed step in a pathway Allosteric regulation...

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Potorous tridactylus Long-nosed Potoroo How Big? A: 10 mm B: 5 cm C: 10 cm D: 40 cm E: 1 m
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Long-nosed Potoroo 35
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Secondary structure of yeast hexokinase alpha-helix beta-sheet
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Hexokinase examples
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G ° = -140 kcal/mole + O 2 + 2 H 2 O
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Glyceraldehyde-3-P + ½ O 2 3-phosphoglycerate + H 2 O G ° = -63 kcal/mole NAD+ + H 2 O NADH + H + + ½ O 2 G ° = 52.7 kcal/mole ADP + P i ATP + H 2 O G ° = 7.3 kcal/mole Glyceraldehyde-3-P + NAD+ + ADP + P i 3-phosphoglycerate + NADH + ATP + H 2 O G ° = -3 kcal/mole
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NAD+ + H 2 O NADH + ½ O 2 G ° = 52.7 kcal/mole ADP + P i ATP + H 2 O G ° = 7.3 kcal/mole glucose + O 2 2 pyruvate + 2 H 2 O G ° = -140 kcal/mole Glucose + 2 NAD+ + 2 ADP + 2 P i 2 pyruvate + 2 NADH + 2 ATP + 4 H 2 O G ° = -20 kcal/mole
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Net reaction rate is: Inhibited by ↑ATP Accelerated by ↑ADP Feedback regulation (principle) End products of biochemical pathways are often inhibitors of the first
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Unformatted text preview: committed step in a pathway Allosteric regulation (mechanism) Binding of ATP to a non-substrate (allosteric) site on the enzyme causes a conformational change that converts the enzyme from an active to an inactive form. ADP stimulation via allosteric activation . Anapleurotic anabolic pathways M. G. Vander Heiden et al., Science 324, 1029 -1033 (2009) Schematic representation of the differences between oxidative phosphorylation, anaerobic glycolysis, and aerobic glycolysis (Warburg effect) M. G. Vander Heiden et al., Science 324, 1029 -1033 (2009) Fig. 3 Metabolic pathways active in proliferating cells are directly controlled by signaling pathways involving known oncogenes and tumor suppressor genes...
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L0710ap - committed step in a pathway Allosteric regulation...

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