Excitation - Excitation-Contraction Coupling Calcium is the...

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Excitation-Contraction Coupling 10/03/2008 10:05:00 Calcium is the Key in contraction Calcium is controlled by the nervous system o Development of Tension Sequence of events Electrical signal sent from motor neuron to skeletal muscle fiber o Action potential o Stimulates muscle Release of Calcium from SR o Calcium binds to regulatory proteins (Troponin) of thin filament Cross bridges form Cross bridge cycling results in tension o Removal of calcium results in relaxation
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Neuromuscular Transmission 10/03/2008 10:05:00 Activation of skeletal muscle is Voluntary Nervous input is required o Signal to neuromuscular junction Single motor neuron can innervate multiple muscle fibers Axon terminal Synaptic end bulb  Synaptic vesicles of NMJ contain  neurotransmitters o Acetylcholine  (ACh) Fuse to motor neuron membrane, release into  Synaptic Cleft between motor neuron and muscle 
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This note was uploaded on 04/03/2008 for the course PSIO 201 taught by Professor Stanescu during the Spring '08 term at University of Arizona- Tucson.

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Excitation - Excitation-Contraction Coupling Calcium is the...

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