05ProteinTrafficLocal - PROTEIN TRAFFICKING AND...

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PROTEIN TRAFFICKING AND LOCALIZATION z PROTEINS SYNTHESIZED IN CYTOPLASM, BUT z BECOME LOCALIZED IN z CYTOPLASM z CYTOPLASMIC MEMBRANE z PERIPLASM z OUTER MEMBRANE z RELEASED IN ENVIRONMENT z HOW? WHAT IS MECHANISM(S) OF LOCALIZATION? SEVEN SEPARATE PROTEIN TRANSPORT MECHANISMS
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INSERTION OF INTEGRAL CYTOPLASMIC MEMBRANE PROTEINS - FOUR NECESSARY COMPONENTS IN MECHANISM z CYTOPLASMIC MEMBRANE PROTEINS CONTAIN “SIGNAL SEQUENCE” - AN ANCHOR 15 - 30 HYDROPHOBIC AMINO ACID RESIDUES NEAR THE N-TERMINUS [e.g., GLYCINE, ALANINE, VALINE, LEUCINE, PHENYLALANINE] SIGNAL SEQUENCE ALLOWS PROTEIN TO BIND MEMBRANE AND BE SOLUBLE IN THE PHOSPHOLIPID MATRIX. z SIGNAL RECOGNITION PARTICLE [Ffh PROTEIN + 4.5 S RNA] SRP BINDS NASCENT PROTEIN (BEING TRANSLATED) AND DELIVERS TO MEMBRANE BOUND RECEPTOR [FtsY] z FtsY RECEPTOR PROTEIN DELIVERS NASCENT MEMBRANE PROTEIN TO TRANSLOCON - [SecYE] z TRANSLOCON [SecYE] INSERTS NASCENT MEMBRANE PROTEIN INTO CYTOPLASMIC MEMBRANE.
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PROTEIN SYNTHESIS IN THE CYTOPLASM NASCENT INTEGRAL
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05ProteinTrafficLocal - PROTEIN TRAFFICKING AND...

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