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326R GLOBAL REGULATION - SIGNAL TRANSDUCTION 1 BACTERIA...

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SIGNAL TRANSDUCTION BACTERIA SENSE CHANGE IN ENVIRONMENT AND RESPOND TO IT TWO COMPONENT SIGNAL TRANSDUCTION SYSTEM PHOSPHO-RELAY SYSTEM SENSOR KINASE DETECTS CHANGE IN ENVIRONMENT (e.g., FOOD) TRANSMITS SIGNAL TO RESPONSE REGULATOR BY PHOSPHORYLATING IT KINASES TRANSFER PHOSPHORYL GROUPS (KINASES CAN PHOSPHORYLATE THEMSELVES) RESPONSE REGULATOR PHOSPHORYLATED PROTEIN CONTROLS TRANSCRIPTION / OR PROCESS 1
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GLOBAL REGULATORY SYSTEMS REGULONS - MANY GENES AND OPERONS CONTROLLED SIMULTANEOUSLY ALLOW CELLS TO RESPOND TO CHANGING ENVIRONMENTS HEAT SHOCK, DAMAGE TO CHROMOSOME, AVAILABILITY OF FOOD (CHEMOTAXIS TO FOOD) EXAMPLES 1. CATABOLITE REPRESSION SYSTEM: SEVERAL OPERONS INVOLVED IN SUGAR CATABOLISM REQUIRE cAMP-CAP POSITIVE ACTIVATOR TO TURN ON TRANSCRIPTION. [THIS SYSTEM IS THE CATABOLITE REPRESSION REGULON] LACTOSE, ARABINOSE, GALACTOSE, RIBOSE OPERONS LACTOSE CONVERTED TO GLUCOSE & GALACTOSE L-ARABINOSE CONVERTED TO D-XYLULOSE-5-PO 4 GALACTOSE CONVERTED TO GLUCOSE-1-PO 4
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