BACTERIAL DISEASES - BIO 326R COMPREHENSIVE BACTERIAL...

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BIO 326R BACTERIAL DISEASES - BASIC INFO, NOT MEANT TO BE COMPREHENSIVE - NOT ASSIGNED SP 2010 DIPHTHERIA (respiratory) C. diphtheriae – Gram+ rods, non-invasive. Airborne nasopharyngeal secretions Symptoms – nasal discharge, pharyngitis, fever, cough Colonization of mucous membranes of oral cavity, secretion of exotoxin (extracellular toxin). Pseudomembrane formation as result of inflammation in pharynx, larynx or trachea consists of WBC, bacteria, killed epithelial cells Airway obstruction, asphyxiation (death). Exotoxin absorption leads to cardiac and kidney damage, death because of heart failure. DPT vaccine (diphtheria, pertussis, tetanus) Treatment with anti-toxin, antibiotics Penicillin (Functional Peptidoglycan) or Erythromycin (and broader spectrum Azithromycin, both macrolides) (inhibit translocation by 50S ribosome subunit). MENINGITIS (central nervous system - inflammation of the meninges – the membranes covering the brain and spinal cord Bacterial –
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