Lecture3.BioSci97

Lecture3.BioSci97 - Announcements Lecture 3 Hourly...

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1 Announcements Lecture 3 Hourly Exam (Friday, Oct. 9) will cover lectures 1 – 6 and the associated readings and problems 20 multiple choice questions (Scantron) in 50 minutes No short answer questions 20% of final grade If you would like to request special seating (e.g. left- handed desk), email me by Monday (Oct. 5) at 6p. I will try to accommodate these requests (in the order I receive them) but there is no guarantee Exams from 2006, 2007, 2008 are posted on the course website. My office hours are MONDAY 1p to 2:50p in 2130 BS3. Official policy of this course: No Make-Up Exams (see syllabus)
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2 Central Dogma I: From DNA to RNA Lecture 3 Bio Sci 97 (B & C) Fall 2009
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3 9. Fill in the two blanks. The nucleic acid to the right is ____ , and the arrow is pointing in the direction from ____ . (A) RNA, 5’ to 3’ (B) RNA, 3’ to 5’ (C) DNA, 5’ to 3’ (D) DNA, 3’ to 5’ (E) None of the above
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4 Sample Question (Lecture 2) 3. On Mars, the living organisms have DNA in which the complementary DNA strands are oriented in a parallel fashion. In all other respects, DNA replication is the same as that on Earth. What would the replication bubble of the Martian DNA look like? The original parental DNA strands are drawn with thick lines and the newly synthesized DNA strands are drawn with thin lines. 5’ 5’ 3’ 3’ 5’ 5’ 3’ 3’ 5’ 5’ 3’ 3’ 5’ 5’ 3’ 3’ 5’ 5’ 3’ 3’ A) B) C) D) E)
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5 Outline Lecture 3 From Lecture 2: DNA structure DNA replication Lecture 3: Central Dogma Transcription Splicing 1. Prokaryotes have no nucleus (e.g. Bacteria) 1. Eukaryotes have a nucleus (e.g. plants, fungi, animals)
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6 The Central Dogma explains how information encoded in DNA (genotype) contributes to a phenotype DNA RNA protein Transcription (Lecture 3) Translation (Lecture 4)
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7 Proteins control phenotype Proteins are enzymes and structural components that largely determine how we function and how we look. For the most part, DNA controls our phenotype by encoding proteins
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8 Intermediate Types of RNA mRNA = messenger RNA tRNA = transfer RNA rRNA = ribosomal RNA snRNA = small nuclear RNA Chemistry and structure of RNA RNA is single-stranded (most of the time) Contains ribose sugar instead of deoxyribose Contains the pyrimidine uracil in place of thymine RNA bases are U,A,G,C U base pairs with A RNA
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9 Transcription
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