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Unformatted text preview: North Carolina Central University Department of Chemistry CHEG 5000 - Advanced Biochemistry Spring, 2011 Homework #1 Directions: Please answer the following questions. Homework is due February 10 at the beginning of class. Thank you. 1. Enzyme kinetics as an approach to understanding mechanism In the following diagram of the first step in the reaction catalyzed by the protease chymotrypsin, the process of general base catalysis is illustrated by the number ________, and the process of covalent catalysis is illustrated by the number _________. A) 1; 2 B) 1; 3 C) 2; 3 D) 2; 3 E) 3; 2 2. Enzyme kinetics as an approach to understanding mechanism Michaelis and Menten assumed that the overall reaction for an enzyme-catalyzed reaction could be written as k 1 k 2 E + S ES → E + P k-1 Using this reaction, the rate of breakdown of the enzyme-substrate complex can be described by the expression: A) k 1 ([E t ] - [ES])....
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