The Trojan Horse - Yanting Wang 10, 2009 The Trojan Horse:...

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Yanting Wang Dec. 10, 2009 The Trojan Horse: Fighting the War Against Bacteria One of the greatest conquests of human ingenuity has been our progress against infectious bacteria. Today, we have only the mute testimony of millions of gravestones to remind us of the lives tragically fallen at the hands of bacteria ranging from airway infections resulting from cystic fibrosis, chronic wound and sinus infections, endocarditis, and medical device infections. It is hard to believe that one of the most dangerous enemies of humans, a species so advanced, so evolved, is the small and less advanced bacteria. The sobering truth is that although we have won many such battles with discoveries of penicillin and its derivatives, the war is still raging. Bacteria are developing new mechanisms to combat antibiotics and evolving better ways to avoid detection. But now, researchers are rearming. After a decade of relative inaction to a seemingly losing battle, pharmaceutical companies and researchers have stepped up their efforts to find new drugs, vaccines, and other treatments to knock back the microbial hordes. It seems that we still have hope. One of the newly, and promising strategies is the old “Trojan Horse” method. The ancient greek poet, Homer, may be surprised at the influence of his story on not only literature but also science. Researchers from the University of Washington, University of Cincinnati, and University of Iowa 1 are collaborated and developed a new and artful approach to fighting bacteria commonly known as the “Trojan Horse” strategy. The “Trojan Horse” as it is famously known for in Homer’s Greek story was used as a decoy to trick the enemy and to invade the unsuspecting town. Now, researchers are using the 1 Kaneko, Y. et al. “The transition metal gallium disrupts Pseudomonas aeruginosa Fe metabolism and has antimicrobial and antibiofilm activity”. Journal of Clinical Investigation, 117(4): 877-887
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This note was uploaded on 02/11/2011 for the course BIOMI 2900 at Cornell University (Engineering School).

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The Trojan Horse - Yanting Wang 10, 2009 The Trojan Horse:...

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