Lecture 11

Lecture 11 - We wont get to include Fungi on Exam II. It...

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2/14/11 We won’t get to include Fungi on Exam II. It will end up on the next exam. Remember, next exam is Monday, Feb 14th 8AM in Disque 109. Exam will also be multiple choice and some short answer. Largely the material from Prokaryotes and Protists. Some cumulative, especially regularly encountered topics.
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2/14/11 Synonymous (‘silent’) mutations – have no effect on the amino acid sequence of the protein, therefore no effect on phenotype and the mutation is ‘hidden from selection’ Non-synonymous mutations – result in an amino acid change, this change may have little or no effect on the function of the protein, and thus little phenotypic effect, or there may be substantial functional and Mutations can have phenotypic effects if they occur in protein-coding regions However, even in this case, many mutations will not have phenotypic effects. Why? Redundancy of genetic code (remember neutral theory)
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Natural selection acts on phenotypic TTC Phe TTA Leu TTG Leu CTT Leu CTC Leu CTA Leu CTG Leu = = = = = = Even though genetic differences exist, selection cannot act on them, because there is no phenotypic variation genotyp e phenotyp e amin o
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Natural selection acts on phenotypic TTC Phe TTA Leu TTG Leu CTT Leu CTC Leu CTA Leu CTG Leu = genotyp e phenotyp e amin o = = = = = =
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2/14/11 TTT Phe TCT Ser TAT Tyr TGT Cys TTC Phe TCC Ser TAC Tyr TGC Cys TTA Leu TCA Ser TAA STOP TGA STOP TTG Leu TCG Ser TAG STOP TGG Trp CTT Leu CCT Pro CAT His CGT Arg CTC Leu CCC Pro CAC His CGC Arg CTA Leu CCA Pro CAA Gln CGA Arg CTG Leu CCG Pro CAG Gln CGG Arg ATT Ile ACT Thr AAT Asn AGT Ser ATC Ile ACC Thr AAC Asn AGC Ser ATA Ile ACA Thr AAA Lys AGA Arg ATG Met* ACG Thr AAG Lys AGG Arg Note: mutations are NOT more frequent in “wobble” positions… they are just more frequently observed because they survived
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2/14/11 The Diversity of Life: “Protists” (Part 2)
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2/14/11 Protistan Evolutionary Lineages Supergroup Excavata (continued) Euglenoids – possess unique interlocking protein strips beneath their plasma membranes. Highly flexible crawlers. Some autotrophs, heterotrophs. Some are facultatively heterotrophs in the dark! Kinetoplastids
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This note was uploaded on 02/13/2011 for the course BIO 124 taught by Professor Dr.duran during the Winter '11 term at Drexel.

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Lecture 11 - We wont get to include Fungi on Exam II. It...

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