lecture 10 - Update Exam returned Thursday Grades posted on...

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1 Update Exam – returned Thursday Grades posted on [email protected] tomorrow afternoon
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2 Lecture 10 Lymphocyte development in primary lymphoid organs B-cell development-Takes place in bone marrow in humans T-cell development-Takes place in thymus
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3 Paths of development - general Hematopoietic Stem cell Lymphoid progenitor - Antigen receptor gene rearrangement Synthesis of pre-ag receptor Synthesis and Expression of ag receptor Elimination of self positive clones Migration to peripheral circulation
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4 Development in bone marrow requires interaction with BM stromal cells & Il-7
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5 B-cell development occurs in stages
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6 allelic exclusion Gene rearrangement can be a ”sloppy” process A productive rearrangement implies a correct reading frame for transcription Both chromosomes have Ig genes Rearrangement of the variable region starts on one chromosome at a time
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7 Two chances for a productive heavy chain to be formed (allelic exclusion)
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8 Four chances for a productive light chain to be formed
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9 Elimination of self positive B-cells – The population of immature B cells is
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This note was uploaded on 02/14/2011 for the course ORGANIC CH 341 taught by Professor Idk during the Spring '11 term at University of Wisconsin Colleges Online.

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lecture 10 - Update Exam returned Thursday Grades posted on...

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