lecture 12 - Update ID diseas e LAD case Parham Text 11.14...

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1 ID diseas e case Parham Text Molecule/gene defect Immune function deficiency LAD 3 11.14 XLA 10 6.8, 11.11 Fig 6.12 X- Hyper IgM 11 11.12 Hyper IgM- AID 12 4.15 IFN- gamm ma recept or 21 8.17,11. 10 X- SCID 14 11.15 ADA 15 11.15 Update Cases to read for problem set 1 Problem set to be handed out Oct 28 Due Tuesday , Nov 9 at 4 pm in lecture
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2 Fill in the chart below with the following choices: NA = no answer – do NOT answer these A.Normal or Increased levels (Ig) or numbers (Cells) B.Decreased or absent levels or numbers ID disease case IgM IgG/IgA T-cells B-cells LAD 3 XLA 10 X-Hyper IgM 11 Hyper IgM- AID 12 IFN- gammma receptor 21 X-SCID 14 ID disease case Germ Ctrs P.carinii infection Gamma globulin trtment LAD 3 XLA 10 X-Hyper IgM 11 Hyper IgM- AID 12 IFN- gammma receptor 21 X-SCID 14 ADA 15 Fill in the chart below with the following choices: A. Yes B. No
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3 Lecture 12- T-cell mediated immunity Effector functions of T-cells
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4 Activation of naive T-cells leads to formation of effector T-cells Naive T-cells are activated in secondary lymphoid organs Two different effector T-cells are formed to protect us from intracellular pathogens CD4 TH1 – intravesicular pathogens-bacteria CD8 CTL– cytoplasmic pathogens-viruses
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5 CD8 effector T-cell prevents viruses from replicating = killer T-cells Secretes molecules that promote inflammation
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6 CD4 effector T-cell, TH1, enhances killing of bacteria that live in infected macrophages Secretes molecules that promote inflammation
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7 Overview of infection with pathogens Effector T-cells (TH1 and CD8 CTL) move from lymph node to infection site Epitope that activated T- cells has to be expressed on infected cells in tissue sites of infection in the form of [MHC+peptide] Effector T-cells Naive, T-cells
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