lecture 13 - Lecture 13 Antibody (humoral) mediated...

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1 Lecture 13 Antibody (humoral) mediated immunity Effector functions of secreted antibodies
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2 CD4 TH 2 cells help B- cells-only in lymph node B-cells present antigen [MHC:peptide] to T-cell CD40:CD40L signals IL-4 CK secretion by T-Cells B-cells secrete antibodies
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3 Isotype switching and somatic hypermutation occur in germinal centers Primary focus B-cells secreting IgM go into the bloodstream through medullary cords Secondary focus B+T-cells cognate pairs go into the cortex and form germinal centers
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4 primary vs secondary responses- isotype and affinity changes Kuby 4th ed. fig 11-15
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5 Antibody effector functions - how antibodies protect from disease Most important *Neutralization - variable region (blocks binding to targets) toxins viruses Opsonization - Fc region Activate the classical complement system-Fc region Lesser importance - Antibody dependent cell cytotoxicity (ADCC Fc region Review antibody structure
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6 Antibody isotypes
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Isotype distribution in body Secreted (pentameric) IgM-blood IgG – blood, extravascular sites, fetus Dimeric IgA - mucous membranes, Secretory piece IgG crosses placenta Dimeric IgA in breast milk
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lecture 13 - Lecture 13 Antibody (humoral) mediated...

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