Lecture 14 - Lec 14 defense against infectious disease 1 Sequence of events in the host response to infection Non pathogens Pathogens 2 What do we

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1 Lec 14 defense against infectious disease
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2 Sequence of events in the host response to infection Non pathogens Pathogens
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3 What do we mean by an effective/protective immune response? Probably every pathogen infection induces in the host both an AMI and/or a CMI response; however, it does not follow that both types of responses are effective/ The type of effective response depends on the pathogen and it’s pathogenesis “Effective/protective” means – the patient will not die Suffer grave consequences Experience sickness
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4 Primary adaptive immune response Results in production of effector cells & molecules to help clear pathogens from body In short term –protects against re- infection with same pathogen In long term-Establishment of memory Expand population of T and B lymphocytes for a particular pathogen
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5 Primary immune response helps prevent re-infection in the short term Memory immune response helps prevent serious infection in long term
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6 Effective/protective immune mechanisms depend on pathogen Antibody mediated immunity “AMI” is important in protection against exotoxins and extracellular bacteria Neutralization of toxins Opsonization of extracellular bacteria– requires IgG Neutralization of viruses - Affects viruses only in extracellular stages Cell mediated immunity “CMI” is important in protection against intravesicular bacteria and viruses during intracellular stage TH1-cell mediated Macrophage “activation” Direct CD8T-cell cytotoxicity
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This note was uploaded on 02/14/2011 for the course ORGANIC CH 341 taught by Professor Idk during the Spring '11 term at Wisconsin.

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Lecture 14 - Lec 14 defense against infectious disease 1 Sequence of events in the host response to infection Non pathogens Pathogens 2 What do we

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