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lecture 15 - Problem set 1 Two parts Part 1 = multiple...

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1 Problem set 1 Two parts Part 1 = multiple choice – hand in scantron sheet only Part 2 = essay-please write neatly, if we can’t read it then no credit Due by 4 pm Tuesday, Nov 9 Open book, open discussion You cannot ask TAs questions about it Posted on [email protected] and I’ll leave copies outside of my office door during normal work hours
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2 Lecture 15 Vaccines How can we prevent infectious disease by providing “immunity” before contact with the pathogen?
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3 Two forms of “preventive” protection against infectious disease can be accomplished Passive immunity –give preformed antibodies by injection Active immunity – you make the immune response yourself before you see the pathogen = vaccination
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4 PASSIVELY ACQUIRED Antibody IMMUNITY Transfer of preformed abs from one host to another ”serum therapy” Done for “speed” in getting immunity Examples: gamma globulins specific antibodies = Host (human or animal) is Hyperimmunized to a particular “antigen”, bled to get “antiserum – example=tetanus immune globulin, anti- snake venom Natural - mother to fetus transfer Temporary protection lasts for half-life of immunoglobulins
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5 Gamma globulin therapy for antibody deficiencies Current preparation = IVIG (intravenous immunoglobulin) Prepared from pool of normal individuals- contain IgG antibodies that the donors have made to vaccines or infections Patient with antibody immunodeficiency must get regular, repeated injections to maintain antibody levels
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6 Examples of Passively acquired Ab immunity Goldsby et al , Kuby Immunology 4th Caution in giving antiserum produced in animal? recipient can make an ab against foreign proteins! –leads to type type 1 hypersensitivity (anaphylaxis) or 3 hypersensitivity reactions (serum sickness) Tetanus immune (human) Globulin or horse antitoxin
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7 Tetanus immune globulin (TIG) From human donor or animal hyperimmunized to tetanus toxoid Only given to someone with a tetanus prone “wound” who has NOT been actively immunized and boosted with tetanus toxoid Human globulin is preferred Horse serum is a foreign protein and can induce an antibody response to horse proteins Can lead to reactions between horse proteins and antibodies
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8 Passive immunotherapy with
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