lecture 16 - Lecture 16 Type 1 hypersensitivity 1 Immune...

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1 Lecture 16 Type 1 hypersensitivity
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2 Immune over-reactions lead to tissue Injury “Hypersensitivity”= overreactions Occurs when there is a constant presence of and/or a lot of antigen + immune response Non-pathogens predominate in hypersensitivity Can lead to tissue destruction by causing chronic inflammation Failure to get rid of antigen Inflammatory events are prolonged as long as antigen remains- may differ somewhat from pathogens
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3 The 4 types of hypersensitivity are organized loosely on basis of effector functions Type I – Immediate IgE, mast cells Type II – Cytotoxic Antibody, IgG, specific for cell associated antigens Type III - Immune complex Antibody, IgG, in form of soluble immune complexes Type IV - Delayed type T-cells
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4 Type 1 Hypersensitivity IgE mediated “allergies”
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5 Type I Hypersensitivity: Mechanisms Immunologic components Isotype switching to IgE IgE produced-binds mast cells Mast cells degranulate Mechanisms producing tissue injury histamine release prostaglandins & leukotrienes secretion
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6 Common Antigens for type1 hypersensitivity Antigens for hypersensitivity called “Allergens” Pollen Animal dander-dried skin and saliva Insect venom-bee stings Dust mites-feces Foods such as peanuts, shellfish
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This note was uploaded on 02/14/2011 for the course ORGANIC CH 341 taught by Professor Idk during the Spring '11 term at University of Wisconsin Colleges Online.

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lecture 16 - Lecture 16 Type 1 hypersensitivity 1 Immune...

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