10.22.09_DiscHmwk - as a template → Topoisomerase...

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Intro Bio 151/153 Discussion Homework; week of 10/26-10/30 Name: Josh Litwicki Discussion Section #: 609 1. Why do we need to replicate our DNA? DNA replication allows us to transfer genetic information from parent cells to daughter cells, perform cell division and maintain cell growth. 2. What are the functions of helicase, primase, ligase, single-strand binding proteins, and topoisomerase in replication? Helicase : untwists DNA’s double helix at replication forks, making them available as template strands. Primase : makes a primer by joining RNA nucleotides, using the parental DNA as a template. Ligase : joins the 3’ end to the rest of the leading strand. Also joins the Okazaki fragments of the lagging strand. Single-stranded binding proteins : binds to and stabilized the single-stranded DNA until it can be used
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Unformatted text preview: as a template. → Topoisomerase : relieves strain in DNA’s double helix by breaking, swiveling, and rejoining DNA strands ahead of the replication fork. 3. Why are RNA primers necessary in replication? → RNA primers are required to begin DNA replication. 4. What purpose do Okazaki fragments serve in the process of replication on the lagging strand? → Okazaki fragments are produced because of the need for DNA polymerase to always synthesize in a 5′ to 3′ direction resulting in a long, continuous strand of DNA. 5. How are Okazaki fragments converted into a continuous strand of DNA? → DNA ligase joins all the sugar-phosphate backbones of the Okazaki fragments into one continuous strand of DNA. 1...
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