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Gene_Regulation

Gene_Regulation - Corepressor substance activates the...

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Genome Organization genome : the complete complement of an organism’s genes, an organism’s genetic material Bacterial genome organization Procaryotic Gene Regulation: OPERON STRUCTURE regulator gene, Promoter site, operator, structural genes Inducible Operon (lac operon) Structural genes normally "off" since the repressor attached to operator region, RNA polymerase cannot attach to promoter. Inducer substance inactivates the repressor, no longer binds to operator, now RNA polymerase can bind to promoter and transcribe the structural genes.
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Repressible Operon (trp operon) Structural genes normally "on" since the inhibitory gene produces an inactive repressor, so RNA polymerase can bind to the promoter and transcribe the structural genes.
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Unformatted text preview: Corepressor substance activates the repressor, which then binds to the operator and turns the structural genes "off" Positive Control: cAMP Receptor Protein (CRP) No Control: Some operators have no repressors (genes expressed at a constant rate) Eucaryotic Genome Organization How is the genome structured? Eucaryotic Gene Expression: Chromosomal Level: DNA packing: DNA methylation: Gene Amplification: Transcriptional Level : Enhancers Transcription Factors Post-Transcriptional Level: mRNA processing: Regulation of mRNA degradation: Transcription level: Post-Translational level: cleavage and modification transport and degradation:...
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