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Slide Show Notes5 (Blank) - Chapter 10 Biomembranes and...

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Chapter 10 Biomembranes and Cell Architecture Lipid Composition and Structural Organization
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Membrane-bound Compartments of the Eukaryotic Cell
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Bilayer Structure of Biomembranes
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Faces of Cellular Membranes
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Classes of Lipids found in Membranes
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Classes of Lipids found in Membranes
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Classes of Lipids found in Membranes
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Lipids and some proteins are mobile in membranes Fluorescence recovery after photobleaching
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Lipid Diffusion-Indicates Membranes are Fluidlike
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Factors Affecting Bilayer Fluidity 1. Lipid Composition 2. Structure of Hydrophobic Tails 3. Temperature 4. Cholesterol Content
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Lipid Composition of Different Cellular Membranes
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Factors Affecting Lipid Composition . Site of synthesis of various lipids -Phospholipids (PL)-synthesized in ER -Sphingolipids-synthesized in Golgi 2. Cell type/function -Intestinal Epithelial Cells -Basolateral face-contacts other epithelial cells and other underlying structures -Apical face-faces lumen of gut -Higher concentration of sphingolipids than basolateral face -Thought to increase the stability of the membrane through hydrogen bonding
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Fig. 6-5 Intestinal Epithelial Cells
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Bilayer Distribution of Membrane Lipids -Different phospholipids are usually more abundant in one leaflet of the membrane than the other -Sphingomyelin and phosphatidylcholine are more abundant on outer leaflet -Phosphatidylethanolamine, phosphatidyl- serine, and phosphatidylinositol are more abundant in inner leaflet -Cholesterol is usually evenly distributed between the two leaflets
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How does asymmetry of lipid distribution arise? -Flip-flopping of lipids is energetically unfavorable
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This note was uploaded on 02/14/2011 for the course BIOL 3030 taught by Professor Deborahvestal during the Spring '11 term at Toledo.

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Slide Show Notes5 (Blank) - Chapter 10 Biomembranes and...

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