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Slide Show Notes7 (Blank) - Chapter 13 Moving Proteins into...

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Chapter 13. Moving Proteins into Membranes and Organelles
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Insertion of secretory proteins into the ER
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Insertion and orientation of membrane proteins
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Type I proteins
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Type II proteins
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Type III proteins
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Type IV proteins
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Membrane and soluble proteins that have been synthesized on the ER can undergo 4 types of post-translational modifications: 1. Glycosylation 2. Formation of disulfide bonds 3. Folding and assembly of multisubunit proteins 4. Specific proteolytic cleavages No. 2 and 3 occur only in the ER and will be covered in this lecture No. 4 occurs in both the ER and the Golgi complex and will be covered in the vesicle traffic lectures Start our discussion of modifications with No. 1
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Most of the proteins synthesized at the rough ER will become glycosylated. Glycosylation is the addition of carbohydrate moieties to proteins and their subsequent modification. The oligosaccharides attached to proteins may be either: 1. O-linked oligosaccharides 2. N-linked oligosaccharides O-linked oligosaccharides are carbohydrate chains that are
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This note was uploaded on 02/14/2011 for the course BIOL 3030 taught by Professor Deborahvestal during the Spring '11 term at Toledo.

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Slide Show Notes7 (Blank) - Chapter 13 Moving Proteins into...

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