lecture13-10 - lecture 12-thyroid and growth hormones! the...

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lecture 12-thyroid and growth hormones •the function of thyroid hormone is both subtle and complex •absence of thyroid hormone is not lethal, but has serious consequences •one of the key determinants of Basal Metabolic Rate (BMR) : BMP: “metabolic rate when a person is at mental and physical rest, but not sleeping, at a comfortable temperature, and has fasted for at least 12 hours”. •this is the energy required for things like: respiration, circulation, synthesis of new molecules (RNA, proteins. ..), maintain ion gradients, maintaining body temperature. ..... About 75% of your daily calories go to basal metabolism.
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Physiologic Effects of Thyroid Hormones: It is likely that all cells in the body are targets for thyroid hormones. Cellular mechanism of action : Thyroid hormone binds to a nuclear receptor and stimulates transcription of genes encoding things like enzymes for oxidative phosphorylation. EFFECTS Metabolism: Thyroid hormones stimulate diverse metabolic activities most tissues, leading to an increase in basal metabolic rate. One consequence of this activity is to increase body heat production, which seems to result, at least in part, from increased oxygen consumption and rates of ATP hydrolysis. A few examples of specific metabolic effects of thyroid hormones include:• Lipid metabolism : Increased thyroid hormone levels stimulate fat mobilization, leading to increased concentrations of fatty acids in plasma. They also enhance oxidation of fatty acids in many tissues. Carbohydrate metabolism
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This note was uploaded on 02/14/2011 for the course MCDB 111 taught by Professor Smith during the Spring '11 term at UCSB.

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lecture13-10 - lecture 12-thyroid and growth hormones! the...

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