Endocrine#4%20ppt.%202010

Endocrine#4%20ppt.%202010 - AdrenalGland RoleinHomeostasis...

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Adrenal Gland Role in Homeostasis Nur 214
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Adrenal Gland
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Adrenal Cortex vs Medulla
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Adrenal Cortex Glucocorticoids Mineralocorticoids Sex Hormones      estrogens Generally of less      importance     
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Glucocorticoids “Steroid Hormones” Synthesized from cholesterol Cortisol – the body’s major glucocorticoid      Necessary to maintain life and protect      the body from stress.      Half life is about 90 minutes.      Primarily deactivated by the liver. WHAT WILL HAPPEN IF LIVER DISEASE?
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Glucocorticoid Regulation
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CORTISOL Gluconeogenesis Protein and Fat into storage Inhibit ADH and ACTH Inhibit bone formation Increase gastric acid secretion Anti-inflammatory actions Immunosuppressive actions
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Cortisol Variations Diurnal Variations ACTH Highest in am Cortisol Highest in the morning(8am)   Lowest in the evening Any type of physical or mental stress results in  increased serum cortisol levels Elevated levels can act like aldosterone Diurnal pattern can be utilized for testing.
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Glucocorticoid Clinical Applications Chronic inflammatory conditions Autoimmune disorders Replacement therapy for deficiency  disorders Dosage tapering is recommended if    treatment regimen is 10 days or    longer.
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CORTISOL TREATMENT  SIDE EFFECTS
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This note was uploaded on 02/14/2011 for the course NUR 214 taught by Professor Criswell during the Spring '08 term at Purdue.

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Endocrine#4%20ppt.%202010 - AdrenalGland RoleinHomeostasis...

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