PHPR202 - PHPR 202 Chapter 4 Pharmacokinetics and Chapter 5...

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PHPR 202 Chapter 4 Pharmacokinetics and Chapter 5 Pharmacodynamics Koh-Knox January 19 and 24, 2011 Chapter 4 Pharmacokinetics Learning objectives 1. Explain the application of pharmacokinetics to clinical practice 2. Identify the four components of pharmacokinetics 3. Discuss factors affecting ADME 4. Explain plasma half-life (t½) to pharmacotherapy. 5. Define the terms: therapeutic range, loading dose, and maintenance dose. 6. Explain how a drug reaches and maintains its therapeutic range (steady state) in the plasma. Chapter 4 Pharmacokinetics What does pharmacokinetics mean? pharmaco : ________________________ kinetics : ___________________________ The goal to taking medicines is getting the drug _____ the target cell for a _______ effect Pharmacokinetics is ADME A bsorption D istribution M etabolism E xcretion (elimination) Absorption of drugs in the body Absorption can affect the time it takes for the drug to produce effect ______________________ Process involving movement of substance across body membranes to _________________ fluids Membranes: skin, mucous, gastrointestinal, respiratory Absorption rate affected by _____________ of administration _____________ flow at site of administration ______________ of drug enteral: po, pr, NG parenteral: IV, IM, SubQ percutaneous: SL, inh, buccal, topical
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Absorption factors associated with route of administration Enteral: _______________, gastric emptying time, motility, formulation, gastric enzymes Parenteral: IV vs IM vs SC, ______________________, temperature of skin Percutaneous: size of area, ______________________, skin disruption, particle size (inhalation) Figure 4.2 Effect of pH on drug absorption Distribution of drugs in the body delivery of drug to the tissues blood and lymphatic fluids volume of distribution –total volume of fluid compartments of body drug formulation Figure 4.3
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PHPR202 - PHPR 202 Chapter 4 Pharmacokinetics and Chapter 5...

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