Jan 27 - Altered Immunity

Jan 27 - Altered Immunity - Organ or bone marrow...

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NURS 216 Spring 2010 Sabra Smith, MS, RN
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Autoimmune Diseases Tolerance/self-tolerance – an organism will not ‘attack’ its own cells Self-tolerance is handled by MHC/HLAs Mechanism of autoimmunity is unclear -genetic? -infectious? -environmental? Examples: rheumatoid arthritis, SLE, scleroderma, IDDM, MG, ulcerative colitis
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Systemic Lupus  Erythematosus Multisystemic, chronic, inflammatory condition Autoantibodies are produced against almost every type of blood cell, many proteins, DNA Autoantibody/DNA complexes deposited in tissues, cause significant damage Manifestations: arthralgias/arthritis, vasculitis and rask, renal disease, anemia, cardiovascular disease Treat with NSAIDs, corticosteroids, immunosuppressants
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Transplantation Problems
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Unformatted text preview: Organ or bone marrow transplants must be matched by HLAs (allogenic) Better MHC/HLA matching decreases chance of a reaction Host vs. Graft Disease – recipient’s immune system attacks transplanted organ/tissue-hyperacute-acute-chronic Graft vs. Host Disease – most often with bone marrow can be acute or chronic Primary Immunodeficiencies Over 100 different syndromes, at least 1/3 are genetic Humoral (B lymphocyte) disorders account for 70% Cellular (T cells) disorders less common Severe Combined Immunodeficiency Syndrome (SCIDS) – genetic mutation causing loss of all immune function, sometimes keep NK cells-can be treated with bone marrow transplant if caught before 3 months...
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This note was uploaded on 02/15/2011 for the course NURS 216 taught by Professor Smith during the Spring '10 term at South Carolina.

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Jan 27 - Altered Immunity - Organ or bone marrow...

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