8-26 Drug Interactions, ADRs, Errors

8-26 Drug Interactions, ADRs, Errors - Drug Interactions...

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Click to edit Master subtitle style 2/16/11 Drug Interactions Adverse Drug Reactions NURS 324 Fall 2010 Dr. Smith
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2/16/11 Drug-Drug Interactions Only requires two drugs (polypharmacy) Possible consequences: -intensification of therapeutic or adverse effects (potentiation) -reduced therapeutic or adverse effects -a unique (idiosyncratic) response
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2/16/11 Pharmacokinetic Drug-Drug Interactions Altered absoprtion: a laxative reduces time for another drug to be absorbed through intestine Altered distribution: two drugs that both bind to albumin Altered metabolism: drugs can reduce or inhibit the activity of CYP enzymes, or compete for the same
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2/16/11 Pharmacodynamic Drug- Drug Interactions Interactions at the same receptor: two drugs compete for the same receptors, usually inhibitory - reversing a narcotic overdose by using naloxone Interactions at different receptors: two drugs may influence the same physiologic process but at different
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2/16/11 Other Drug-Drug Interactions Direct chemical interactions: some drugs will mix and form a precipitate
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8-26 Drug Interactions, ADRs, Errors - Drug Interactions...

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