8-31 PNS, muscarinic

8-31 PNS, muscarinic - Peripheral Nervous System...

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Click to edit Master subtitle style 2/16/11 Peripheral Nervous System Neuropharmacology NURS 324 Fall 2010 Dr. Smith
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2/16/11 Peripheral Nervous System Refer to previous texts for a review of the nervous system, functions of the sympathetic and parasympathetic divisions We are jumping into discussion of the neurotransmitters used by the autonomic division and the different receptors
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2/16/11 Review Topics General functions of parasympathetic and sympathetic nervous systems Steps in neurotransmission Feedback regulation, feedback loops Baroreceptor reflex Autonomic tone
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2/16/11 Anatomy Review
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2/16/11 Players in the Peripheral Nervous System Acetylcholine (Ach) Norepinephrine (NE) Epinephrine (Epi) Cholinergic (respond to Ach) nicotinicN, nicotinicM, muscarinic Adrenergic (respond to NE, Epi) alpha1, alpha2, beta1, beta2, dopamine neurotransmit ters recepto rs
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2/16/11 Transmitters at specific sites of Peripheral Nervous
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2/16/11 Pointers The response to a drug depends on the type of receptor that is activated or blocked Different receptor subtypes are located on various organs, leading to specific responses in different parts of the body when that subtype is activated or blocked
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2/16/11 Cholinergic and Adrenergic Receptor Subtypes
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2/16/11 Functions of Cholinergic Receptors NicotinicN activation: increases ganglionic transmission, increases epi release from adrenal medulla NicotnicM activation: causes contraction of skeletal muscles Muscarinic activation: varied based on organ location, memorize Table 13-2
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2/16/11 Life Cycle of Ach Note that transmission is terminated by enzymatic degradation of ACh and not by uptake of intact ACh back into the nerve terminal. (Acetyl CoA = acetylcoenzyme A, ACh = acetylcholine, AChE = acetylcholinesterase.)
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2/16/11 Cholinergic Medications Most act at the receptor, some interfere with AchE and prevent Ach
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8-31 PNS, muscarinic - Peripheral Nervous System...

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