9-7 Adrenergic Agonists and Antagonists

9-7 Adrenergic Agonists and Antagonists - Adrenergic...

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Click to edit Master subtitle style 2/16/11 Adrenergic Agonists and Antagonists NURS 324 Fall 2010 Dr. Smith
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2/16/11 Adrenergic Receptors Now we are discussing only the sympathetic nervous system Adrenergic receptors are activated by norepinephrine (NE), epinephrine (Epi), and dopamine (DA) Subtypes are: alpha1, alpha2, beta1, beta2, dopamine
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2/16/11 Activation of Receptor Subtypes Alpha1 Vasoconstriction (skin, viscera, mucous membranes) Ejaculation Contraction of bladder neck and prostate Alpha2 Located in presynaptic junction Minimal clinical significance Go back to Table 13-3 and review!
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2/16/11 Activation of Receptor Subtypes Beta1 Heart Increases Heart rate Force of contraction Velocity of conduction in AV node Beta2 Bronchial dilation Relaxation of uterine muscle Vasodilation (heart, lungs, skeletal muscle) Dopamine receptor activation dilates renal blood vessels (only significant DA receptors are in kidneys)
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2/16/11 Specificity of Adrenergic Transmitters for Receptors Epi activates all alpha and beta receptors (Epi released from adrenal medulla for ‘fight-or- flight’ response – only time beta2 responses are all needed together) NE activates both alphas and beta1 receptors DA activates alpha1, beta1, and dopamine receptors
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2/16/11 Life Cycle of Norepinephrine
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2/16/11 Adrenergic Agonists MOA: activation of adrenergic receptors Four ways to do this: Direct receptor binding (only direct method) Promotion of NE release – amphetamines, ephedrine Inhibition of NE reuptake –cocaine, some antidepressants
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Chemical Classification Catecholamines (catechol & amine group) NE, Epi, DA, isoproterenol, dobutamine Shared properties:
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9-7 Adrenergic Agonists and Antagonists - Adrenergic...

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