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9-23 F and E drugs, RAAS

9-23 F and E drugs, RAAS - Cliquez pour modifier le style...

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Cliquez pour modifier le style des sous-titres du masque 2/16/11 Diuretics Fluid and Electrolyte NURS 324 Fall 2010 Dr. Smith
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2/16/11 Renal A&P Review
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2/16/11 Structure/Function of Nephrons Three Main Processes - filtration (at glomerulus) -reabsorption (PCT, Henle loop, DCT) -secretion (PCT)
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2/16/11 Formation of Urine
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2/16/11 Diuretics All types share the same basic MOA: blockage of Na and Cl reabsorption -reduced Na/Cl reabsorption also blocks H20 reabsorption The effect on urine production is directly related to the amount of Na/ Cl reabsorption that a diuretic blocks
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2/16/11 Diuretics General Uses: -treatment of hypertension -edema related to heart, renal, or liver failure General Adverse Effects: -hypovolemia -acid/base imbalances -other electrolyte imbalances
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2/16/11 Categories Loops – “high-ceiling” Thiazides Osmotics Potassium-sparing (aldosterone antagonists and non- aldosterone antagonists) Effectiveness of each type depends upon its site of action in the kidney
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2/16/11 Sites of Action of Diuretics
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2/16/11 Loop Prototype: Furosemide (Lasix) MOA: blocks Na/Cl reabsorption in the thick segment of ascending Loop of Henle Produces significant diuresis Used when significant fluid excess exists: pulmonary edema r/t CHF, edema or HTN untreated by other diuretics Furosemide can be effective even
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2/16/11 Furosemide (Lasix) Pharmacokinetic s Administration/A bsorption Adverse Effects Hypotension
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2/16/11 Furosemide (Lasix) Interactions Digoxin – risk of dig toxicity in people who are hypokalemic Ototoxic drugs Potassium-sparing diuretics
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  • Fall '10
  • Smith
  • pulmonary edema, Diuretic, Furosemide, Effects Administration/A Pharmacokinetic, Adverse Effects Administration/A

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