9-23 F and E drugs, RAAS

9-23 F and E drugs, RAAS - Cliquez pour modifier le style...

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Unformatted text preview: Cliquez pour modifier le style des sous-titres du masque 2/16/11 Diuretics NURS 324 Fall 2010 Dr. Smith 2/16/11 Renal A&P Review 2/16/11 Structure/Function of Nephrons Three Main Processes- filtration (at glomerulus)-reabsorption (PCT, Henle loop, DCT)-secretion (PCT) 2/16/11 Formation of Urine 2/16/11 Diuretics All types share the same basic MOA: blockage of Na and Cl reabsorption-reduced Na/Cl reabsorption also blocks H20 reabsorption The effect on urine production is directly related to the amount of Na/ Cl reabsorption that a diuretic blocks 2/16/11 Diuretics General Uses: -treatment of hypertension-edema related to heart, renal, or liver failure General Adverse Effects:-hypovolemia-acid/base imbalances-other electrolyte imbalances 2/16/11 Categories Loops high-ceiling Thiazides Osmotics Potassium-sparing (aldosterone antagonists and non- aldosterone antagonists) Effectiveness of each type depends upon its site of action in the kidney 2/16/11 Sites of Action of Diuretics 2/16/11 Loop Prototype: Furosemide (Lasix) MOA: blocks Na/Cl reabsorption in the thick segment of ascending Loop of Henle Produces significant diuresis Used when significant fluid excess exists: pulmonary edema r/t CHF, edema or HTN untreated by other diuretics Furosemide can be effective even 2/16/11 Furosemide (Lasix) Pharmacokinetic Administration/A Adverse Effects Hypotension 2/16/11 Furosemide (Lasix)...
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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9-23 F and E drugs, RAAS - Cliquez pour modifier le style...

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