10-19 HTN Drugs_1 - Hypertension and Its Treatment NURS 324...

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Click to edit Master subtitle style 2/16/11 Hypertension and Its Treatment NURS 324 Fall 2010 Dr. Smith
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2/16/11 Hemodynamics Review Pulmonary circulation Systemic circulation Comparison of arteries and veins
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2/16/11
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2/16/11 Control of Blood Flow Flow = ΔP/R and also affected by viscosity Blood flow around the whole body is called cardiac output CO = HR x SV
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2/16/11 Terminology Review Stroke volume - affected by contractility, preload and afterload SV= EDV - ESV Preload - venous return to the heart, AKA EDV Afterload – the pressure the LV must overcome to eject blood
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2/16/11 Control of Stroke Volume Main determinant is venous blood return Starling’s Law: more venous return increases contractility, thereby increasing SV In ventricular failure, the myocardium can’t respond to increased volume and blood backs up behind the failing ventricle
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2/16/11 Blood Pressure Control AP = PR x CO BP = SVR x CO BP normally controlled by ANS, RAAS, kidneys Natriuretic peptides: A(trial)NP and B(rain)NP, produced by myocytes of atria and ventricles, reduce IVF volume, cause diuresis and
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2/16/11 Hypertension (HTN) Joint National Commission 7 – BP recs
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2/16/11 Hypertension The Silent Killer (50,000,000 people in U.S.) Increased risk of MI, CVAs, renal failure, HF Primary (90%) and Secondary (10%) Lifestyle modifications are very effective -weight loss, Na restriction, DASH diet, ETOH reduction, cardiovascular
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2/16/11 HTN Drugs Already Studied β-blockers α1-blockers Clonidine (Catapres)
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2/16/11 HTN Drugs Already Studied Diuretics ACE Inhibitors Angiotensin Receptor Blockers
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