antimicrobials part II

antimicrobials part II - Antimicrobials The Final Frontier...

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Click to edit Master subtitle style 2/16/11 Antimicrobials: The Final Frontier NURS 324 Fall 2010 Dr. Smith
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2/16/11 Tuberculosis Causitive agent is Mycobacterium tuberculosis Global epidemic, especially in developing countries Transmitted in aerosolized (airborne) sputum Rapid immune system response keeps infection subclinical in most people
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2/16/11 Tuberculosis Testing Screening done by PPD/tuberculin skin test Presence and larger area of induration indicates exposure to TB If a PPD is positive, further investigation needed to check for latent vs. active TB -CXR -culture of sputum samples
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2/16/11 TB Treatment Latent TB: isoniazid for 6-9 months Active TB: multi-drug combinations used -isoniazid -rifampin -ethambutol -pyrazinamide -all four for 2 months, then usually reduce to isoniazid and rifampin for “First-line” TB drugs
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2/16/11 Isoniazid (INH) Very effective against mycobacteria MOA: some type of disruption of cell wall synthesis M. tuberculosis can develop resistance to INH Is effective by itself for latent TB, needs to be combined with other drugs for active TB
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2/16/11 Isoniazid Pharmacology Administration/A bsorption Adverse Effects Peripheral neuropathy
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