antimicrobials part II

antimicrobials part II - Antimicrobials: The Final Frontier...

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Click to edit Master subtitle style 2/16/11 Antimicrobials: The Final Frontier NURS 324 Fall 2010 Dr. Smith
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2/16/11 Tuberculosis Causitive agent is Mycobacterium tuberculosis Global epidemic, especially in developing countries Transmitted in aerosolized (airborne) sputum Rapid immune system response keeps infection subclinical in most people
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2/16/11 Tuberculosis Testing Screening done by PPD/tuberculin skin test Presence and larger area of induration indicates exposure to TB If a PPD is positive, further investigation needed to check for latent vs. active TB -CXR
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2/16/11 TB Treatment Latent TB: isoniazid for 6-9 months Active TB: multi-drug combinations used -isoniazid -rifampin -ethambutol -pyrazinamide -all four for 2 months, then usually “First-line” TB drugs
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2/16/11 Isoniazid (INH) Very effective against mycobacteria MOA: some type of disruption of cell wall synthesis M. tuberculosis can develop resistance to INH Is effective by itself for latent TB, needs to be combined with other drugs for active TB
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2/16/11 Isoniazid Pharmacology Administration/A Adverse Effects Peripheral
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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antimicrobials part II - Antimicrobials: The Final Frontier...

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