NSAIDS and APAP FINAL

NSAIDS and APAP FINAL - Cliquez pour modifier le style des...

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Cliquez pour modifier le style des sous-titres du masque 2/16/11 COX Inhibitors: NSAIDs NURS 324 FALL 2010 Dr. Smith
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2/16/11 Cyclooxygenase (COX) An enzyme found all around the body COX converts arachidonic acid into prostaglandins, prostacyclin, and thromboxane A2 ( prostanoids ) Where have we seen these compounds before?
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2/16/11
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2/16/11 Good COX vs. Bad COX COX-1 found in most tissues handles upkeep of body tissues (through the synthesis of its products) -protection of gastric mucosa -maintains renal bloodflow -helps with platelet aggregation COX-1 is the housekeeper of the body, or the GOOD COX
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2/16/11 Good COX vs. Bad COX COX-2 found in the blood vessels, kidneys, brain, colon, and is released from injured tissues In blood vessels and kidneys, COX-2 promotes vasodilation In brain, COX-2 causes fever and PAIN In injured tissue, COX-2 causes inflammation and PAIN
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2/16/11 Good COX vs. Bad COX So, when drugs that inhibit COX are given, the actions of COX will be reduced Effects of inhibiting COX-1: Effects of inhibiting COX-2:
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2/16/11 COX Inhibitors One of the most widely used groups of drugs Over 70 million Rx, 30 billion OTC per year General uses: arthritis, bursitis, mild- moderate pain, fever, menstrual problems Aspirin (ASA) reduces risk of MIs and CVAs
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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NSAIDS and APAP FINAL - Cliquez pour modifier le style des...

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