Principles of antimicrobial therapy

Principles of antimicrobial therapy - Principles of...

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Click to edit Master subtitle style 2/16/11 Principles of antimicrobial therapy and penicillins NURS 324 Fall 2010 Dr. Smith
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2/16/11 MICROBIAL CLASSIFICATIONS Acellular microbes Prions viruses Cellular microbes -procaryotes (bacteria) -eucaryotes (algae, fungi, protozoa, etc)
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2/16/11 Classification and Naming Morphology -spherical or coccoid (cocci) -rod-shaped (bacillus) -spiral-shaped (spirochetes) Staining -gram positive or negative -acid-fast or non-acid-fast
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2/16/11 Classification and Naming Oxygen requirements -aerobic -anaerobic -other variations Bacteria names are genus and species Klebsiella pneumoniae (K. pneumoniae)
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2/16/11 Mechanisms of antimicrobials Selective toxicity: a drug can destroy a target organism without damaging nearby cells Disruption of bacterial cell wall or membrane Inhibition of a bacteria-specific enzyme Disruption of bacterial protein
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2/16/11 Murder vs. control Bactericidal agents are directly lethal to bacteria at clinical levels Bacteriostatic agents slow bacterial growth but don’t eliminate them -the host’s immune system must finish the job of elimination
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2/16/11 Microbial resistance Several species of bacteria have developed resistance to once- effective antibiotics Different mechanisms and methods that bacteria can develop resistance Technically, the microbe, not the host, becomes resistant Drug sensitivity testing can
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Antibiotic use and resistance Use of antibiotics indirectly promotes antibiotic resistance Normal microbial behavior/function: -microbes secrete chemicals that are toxic to other species of microbes
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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Principles of antimicrobial therapy - Principles of...

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