Antipsychotics and Sedative-Hypnotics

Antipsychotics and Sedative-Hypnotics - Antipsychotics and...

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Click to edit Master subtitle style 2/16/11 Antipsychotics and Sedative- Hypnotics NURS 324 Fall 2010 Dr. Smith
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2/16/11 Antipsychotic Medications A wide group of medicines Used for many conditions such as schizophrenia, delusional disorders, bipolar disorder Entered into use in the 1950s First-generation (conventional) and second-generation (atypicals)
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2/16/11 Schizophrenia One of the most common uses for antipsychotics A chronic disorder of disordered thinking and separation from reality, usually emerges during adolesence Positive, negative, and cognitive symptoms
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2/16/11 First-Generations (FGAs) MOA: block several receptors in the CNS – dopamine, Ach, histamine, norepinephrine Antipsychotic effects through blockage of dopamine2 receptors? Classified by potency: low, medium, high
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2/16/11 FGAs Low-potency: chlorpromazine (Thorazine) Medium-potency: loxapine (Loxitane) High-potency: haloperidol (Haldol) Category differences in side effects such as extrapyramidal effects,
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2/16/11 FGA Uses Schizophrenia -improvement takes 2-4 weeks, several months for full effect -positive symptoms respond best Bipolar disorder Tourette’s syndrome
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FGA Adverse Effects: EPS Extrapyramidal symptoms mainly due to blockade of D2 receptors? -three occur early after starting FGAs,
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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Antipsychotics and Sedative-Hypnotics - Antipsychotics and...

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