Asthma, Allergic Rhinitis, and Cold Medications

Asthma, Allergic Rhinitis, and Cold Medications - Asthma,...

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Click to edit Master subtitle style 2/16/11 Asthma, Allergic Rhinitis, and Cold Medications NURS 324 Fall 2010 Dr. Smith
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2/16/11 Asthma A chronic, inflammatory disease of the respiratory system Some type of allergen binds to IgE on mast cells, which causes release of several inflammatory mediators Inflammatory mediators cause immediate bronchoconstriction,
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2/16/11
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2/16/11
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2/16/11 Drugs for Asthma Medication categories: anti- inflammatories and bronchodilators Anti-inflammatories -glucocorticoids (inhaled and PO) -leukotriene modifiers Bronchodilators
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2/16/11 Administration of Inhaled Inhalation has several advantages Metered Dose Inhalers (MDIs) -require hand-lung coordination, only small amount reaches the lungs -spacers increase delivery to lungs Dry-Powder Inhalers (DPIs)
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2/16/11 Glucocorticoids Taken daily for long-term control All asthma patients except for those with very mild symptoms need to be on one MOA: decrease synthesis of inflammatory mediators and decreased activity of inflammatory
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2/16/11 Glucocorticoids Pharmacokinetics Administration -usually inhaled -PO for severe cases, use for brief duration Effects develop slowly; not for stopping an ongoing attack! Adverse Effects: inhaled Oropharyngeal candidiasis Dysphonia both can be reduced Adrenal suppression possible with long-term,
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2/16/11
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2/16/11 Glucocorticoid Adverse Adverse effects become a problem with long-term (~10-14 days and longer) use and at high doses Osteoporosis, hyperglycemia, PUD Growth suppression (in children) Adrenal suppression – must supplement during times of physical
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Asthma, Allergic Rhinitis, and Cold Medications - Asthma,...

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