Cholesterol meds, anticoagulants

Cholesterol meds, - Click to edit Master subtitle style Cholesterol and lipid lowering agents anticoagulants NURS 324 Fall 2010 Dr Smith Coronary

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Unformatted text preview: Click to edit Master subtitle style Cholesterol and lipid- lowering agents, anticoagulants NURS 324 Fall 2010 Dr. Smith Coronary heart disease (CHD)  AKA Coronary Artery Disease (CAD)  Due to thickening and narrowing of the coronary arteries from plaque buildup “atherosclerosis”  Mild CAD causes problems such as angina  Severe CAD can cause an MI  Atherosclerosis can develop in any artery  High cholesterol levels are directly related to cholesterol  Physiologic functions: component of cell membranes, necessary for several hormones, part of bile salts for fat metabolism  Some cholesterol is obtained from the diet (exogenous), some is created by the body (endogenous)  Endogenous cholesterol is much larger percentage  Dietary cholesterol has little effect on blood lipoproteins  Molecules that transport cholesterol and triglycerides (TGLs) through the blood  They are classified according to the content or density of Classes of lipoproteins  VLDLs – very low density – contain mainly TGLs in their core-deliver TGLs to muscle and adipose tissue-role in CAD is unclear  LDLs – low density – contain mainly cholesterol in their core-deliver cholesterol to peripheral tissues  HDLs – high density – contain mainly Cholesterol levels  Because cholesterol and TGL levels are related to atherosclerosis and CAD, keeping them below certain levels helps prevent or delay CAD  The National Cholesterol Education Program is an expert group that issues recommendations on desirable cholesterol and TGL levels  These levels are just one risk factor for the Treatment of high ldl/tgl  Aggressiveness of treatment increases when patients have more CAD risk factors  Try therapeutic lifestyle changes (TLCs) first!-limitation of cholesterol and fat in diet-weight control, exercise, stop smoking  When/if medications become necessary, continue dietary restrictions!!!  Cholesterol/TGL meds are most effective Classes of lipid medications  HMG-CoA reductase inhibitors (statins)  Bile acid sequestrants -colesevelam (Welchol)  Nicotinic acid  Fibrates statins  MOA: inhibits a liver enzyme (HMG-CoA reductase) that is necessary to produce cholesterol and allows liver to “clean out” more LDL cholesterol  Effects: lower of LDL levels by an average of 25%, some as much as 63%, moderately...
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This note was uploaded on 02/15/2011 for the course NURS 324 taught by Professor Smith during the Fall '10 term at South Carolina.

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Cholesterol meds, - Click to edit Master subtitle style Cholesterol and lipid lowering agents anticoagulants NURS 324 Fall 2010 Dr Smith Coronary

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