{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Cholesterol meds, anticoagulants

Cholesterol meds, anticoagulants - Cholesterolandlipid...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Click to edit Master subtitle style  2/16/11 Cholesterol and lipid- lowering agents,  anticoagulants NURS 324 Fall 2010 Dr. Smith
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
 2/16/11 Coronary heart disease (CHD) AKA Coronary Artery Disease (CAD) Due to thickening and narrowing of the  coronary arteries from plaque buildup  “atherosclerosis” Mild CAD causes problems such as angina Severe CAD can cause an MI Atherosclerosis can develop in any artery High cholesterol levels are directly related to 
Background image of page 2
 2/16/11 cholesterol Physiologic functions: component of cell  membranes, necessary for several hormones,  part of bile salts for fat metabolism Some cholesterol is obtained from the diet  (exogenous), some is created by the body  (endogenous) Endogenous cholesterol is much larger  percentage Dietary cholesterol has little effect on blood 
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
 2/16/11 lipoproteins Molecules that  transport cholesterol  and triglycerides  (TGLs) through the  blood They are classified  according to the  content or  density  of 
Background image of page 4
 2/16/11 Classes of lipoproteins VLDLs – very low density – contain mainly  TGLs in their core -deliver TGLs to muscle and adipose tissue -role in CAD is unclear LDLs – low density – contain mainly  cholesterol in their core -deliver cholesterol to peripheral tissues HDLs – high density – contain mainly  cholesterol in their core
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
 2/16/11 Cholesterol levels Because cholesterol and TGL levels are  related to atherosclerosis and CAD, keeping  them below certain levels helps prevent or  delay CAD The National Cholesterol Education Program  is an expert group that issues  recommendations on desirable cholesterol  and TGL levels These levels are just one risk factor for the  development of CAD!!!
Background image of page 6
 2/16/11
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
 2/16/11 Treatment of high ldl/tgl Aggressiveness of treatment increases when  patients have more CAD risk factors Try therapeutic lifestyle changes (TLCs) first! -limitation of cholesterol and fat in diet -weight control, exercise, stop smoking When/if medications become necessary,  continue dietary restrictions!!! Cholesterol/TGL meds are most effective  when used as primary prevention
Background image of page 8
 2/16/11 Classes of lipid medications HMG-CoA reductase inhibitors (statins) Bile acid sequestrants  -colesevelam (Welchol) Nicotinic acid Fibrates
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
 2/16/11 statins MOA: inhibits a liver enzyme (HMG-CoA  reductase) that is necessary to produce  cholesterol and allows liver to “clean out”  more LDL cholesterol Effects: lower of LDL levels by an average of  25%, some as much as 63%, moderately 
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}