Endocrine drugs

Endocrine drugs - Click to edit Master subtitle style...

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Unformatted text preview: Click to edit Master subtitle style Endocrine drugs: thyroid, pituitary, and adrenal hormones NURS 324 Fall 2010 Dr. Smith Thyroid regulation Thyroid gland physiology  Active hormones: T3 and T4  These hormones are >99.5% protein bound  Physiologic effects: increased metabolic rate, cardiac stimulation, promotion of growth and development  Iodide is a necessary nutrient for T3 and T4 formation in the thyroid gland  Thyroid function tests include TSH levels, T4 and T3 (total or free) hypothyroidism  Low levels of T3/T4  When severe, called myxedema  In adults, cause is commonly a primary disorder (problem with the thyroid gland)  Manifestations include pale, swollen face, cold/dry skin, hair changes, low HR and temperature, fatigue, cold intolerance, confusion  Symptoms worsen with worsening deficiency Levothyroxine (synthroid,  Synthetic T4, is converted to T3 in the body  Available in several different generic and brandnames  One of the few drugs for which generic formulations may not be interchangeable  Recommendations from specialty endocrine and thyroid groups are to take the same brand-name levothyroxine drug and to monitor carefully if a switch is made levothyroxine Pharmacokinetics  Admin/absorption-PO, empty stomach, usually AM-IV if PO impossible  Distribution & metabolism-very highly protein-...
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