BIO%20328%20Resistance%20to%20Blood%20Flow%20and%20Fluid%20Exchange%20Lecture%205%20Blackboard%20Fal

BIO%20328%20Resistance%20to%20Blood%20Flow%20and%20Fluid%20Exchange%20Lecture%205%20Blackboard%20Fal

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1 Vascular System MAP = CO x R , where MAP = mean arterial blood pressure ( P), mmHg CO = cardiac output (F), liters/min = heart rate x stroke volume R = peripheral resistance (TPR, SVR) ( r 4 ) / ( 8 L )
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2 Local and Extrinsic Control of Arteriolar Radius Arterioles play 2 major roles: Determine the relative distribution of blood flow to individual organs Determine resistance to blood flow across the entire CVS
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3 Fig. 12.33 Total Blood Flow is Constant P is Constant Effects of Changes in Arteriolar Radius on the Relative Distribution of Blood Flow Flow = P / R Fig. 12.33 Total Blood Flow is Constant Across „Organs 1,2,3,4,5‟ P is Constant Effects of Changes in Arteriolar Radius on the Relative Distribution of Blood Flow For “Organ 3” ↑Flow = P / ↓R For “Organ 2” ↓ Flow = P / ↑ R
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4 Local and Extrinsic Control of Arteriolar Radius TYPE MECHANISM RESPONSE LOCAL Myogenic activity stretch due to pressure vasoconstrict Paracrines from metabolism O 2 , CO 2 , H + , K + , osmolarity vasodilate Paracrine signal molecules nitric oxide(EDRF ), histamine, adenosine vasodilate endothelin-1 vasoconstrict EXTRINSIC Nervous sympathetic (NE receptor) vasoconstrict Hormonal epinephrine ( 2 receptors) vasodilate angiotensin II vasoconstrict atrial natriuretic peptide (ANF) vasodilate antidiuretic hormone (ADH, vasopressin) vasoconstrict Extrinsic Control of Arteriolar Radius 1 2
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BIO%20328%20Resistance%20to%20Blood%20Flow%20and%20Fluid%20Exchange%20Lecture%205%20Blackboard%20Fal

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