Lecture 6 - Synaptic Transmission 2 Synaptic Transmission 1...

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Synaptic Transmission 2
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Synaptic Transmission 1. Action potential travels down axon and invades nerve terminal causing a depolarization 2. Depolarization opens voltage-gated Ca 2+ channels 3. Influx of Ca 2+ ions into nerve terminal raises Ca 2+ concentration 4. Increased Ca 2+ concentration promotes fusion of synaptic vesicles with cell membrane 5. Release of neurotransmitter into synaptic cleft 6. Neurotransmitter binds to neurotransmitter receptor on post-synaptic cell causing channels to open 7. Ion flow through channels changes membrane potential, possibly triggering an action potential 8. Neurotransmitter unbinding and removal
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exocytosis synaptic delay
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Intracellular and Extracellular Fluids Internal External (in mM) K + 125 5 Na + 12 120 Cl - 5 125 Ca 2+ 1 x 10 -4 (100 nM) 2 A - 108 0 A - = proteins, amino acids (aspartate and glutamate), inorganic ions (sulfate and phosphate), nucleotides, DNA, RNA
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Ca 2+ binding proteins Na-Ca exchanger
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acetylcholine (ACh) excitatory Neuromuscular Junction (NMJ)
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Exocytosis
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freeze-fracture electronmicrograph
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thin section electronmicrograph
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Exocytosis
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exocytosis synaptic delay
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Synaptic Transmission 1. Action potential travels down axon and invades nerve terminal causing a depolarization 2. Depolarization opens voltage-gated Ca 2+ channels 3. Influx of Ca 2+ ions into nerve terminal raises Ca 2+ concentration 4. Increased Ca 2+ concentration promotes fusion of synaptic vesicles with cell membrane 5. Release of neurotransmitter into synaptic cleft 6. Neurotransmitter binds to neurotransmitter receptor on post-synaptic cell causing channels to open 7. Ion flow through channels changes membrane potential, possibly triggering an action potential 8. Neurotransmitter unbinding and removal
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Single Channel Recording 2 pA (10 -12 amps)
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Single Channel Conductance
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This note was uploaded on 02/15/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture 6 - Synaptic Transmission 2 Synaptic Transmission 1...

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