Lecture 8 - Lecture 8 Intrinsic Electrophysiological...

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Intrinsic Electrophysiological Properties of Neurons 2 Lecture 8
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143 genes
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1.0 0.5 -120 -80 -40 0 40 threshold resting membrane potential high threshold low threshold Classification based on threshold for activation I Na I K - delayed rectifier I C - large Ca 2+ activated K + channel Activation Curve - fraction of channels that are open
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1.0 0.5 -120 -80 -40 0 40 threshold resting membrane potential high threshold low threshold I Na,P - Na + current I A - K + current I D - K + current I M - K + current I AHP - K + current I T - Ca 2+ current I H - cation current Classification based on threshold for activation I Na I K - delayed rectifier I C - large Ca 2+ activated K + channel Activation Curve - fraction of channels that are open
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1.0 0.5 -120 -80 -40 0 40 threshold resting membrane potential high threshold low threshold I A - K + current I D - K + current I T - Ca 2+ current Classification based on threshold for activation Steady State Inactivation - fraction of channels that are in the closed state i.e. not inactivated
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Closed v. fast fast v. slow slow Open Inactivated At Vm = -80 mV v. fast
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This note was uploaded on 02/15/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture 8 - Lecture 8 Intrinsic Electrophysiological...

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