Lecture4 - Lecture 4 Action Potentials I ion permeation ion...

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Lecture 4 Action Potentials I ion permeation ion selectivity channel gating
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voltage-gated channels
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s ubstituted c ystene a ccessibility m easurements
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6 membrane spanning domains 2 membrane spanning domains
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S4 = voltage-sensor positively charged residues sense membrane potential S4 generally hydrophobic +ve charges every third residue
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voltage sensor separate domain to core
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S4-S5 linker helix connects the two domains
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Closed Open
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Closed Open
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Closed v. fast fast v. slow slow Open Inactivated At Vm = -80 mV v. fast Closed Open Inactivated At Vm = +10 mV Kinetic Properties of Voltage-Gated Channels voltage-dependent rate constants
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V m -80 +10 Fraction open 0 - 1 -
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Closed v. fast fast v. slow slow Open Inactivated At Vm = -80 mV v. fast Closed Open Inactivated At Vm = +10 mV V m -80 +10 Fraction open 0 - 1 -
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Open Closed Inactivated N-type extracellular intracellular selectivity filter
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Open Closed Inactivated N-type extracellular intracellular selectivity filter
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Closed v. fast fast v. slow slow Open Inactivated At Vm = -80 mV v. fast Closed Open Inactivated At Vm = +10 mV
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Transient voltage change produced by varying ion conductances Voltage-gated potassium and sodium channels Action Potential
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Passive Membrane Properties RC circuit lipid bilayer = capacitor ion channels = resistor R C
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V m = I m x R
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R C
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This note was uploaded on 02/15/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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Lecture4 - Lecture 4 Action Potentials I ion permeation ion...

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