lecture5 - Synaptic Transmission 1 Structure and Function...

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Unformatted text preview: Synaptic Transmission 1 Structure and Function of Neurotransmitter Receptors- integral ion channel, gated by ligand binding- multiple subunits- fast synaptic transmission Acetylcholine- nicotinic GABA - GABA A Glycine Glutamate - AMPA- Kainate- NMDA 100 genes- ligand binding activates G-protein- single polypeptide- 7 membrane spanning regions- slow synaptic transmission Acetylcholine - muscarinic GABA- GABA B Glutamate- metabotropic Noradrenaline Serotonin- 5Ht1 ATP- P 2Y , P 2U Neuropeptides - substance P Dopamine 500 genes G-Protein Linked Receptors Ligand-Gated Ion Channels Excitatory- cation selective Na + , K + acetylcholine, glutamate Inhibitory- anion selective Cl- GABA, glycine Hydropathy Plot amphipathic leader sequence Structure of the Nicotinic Acetylcholine Receptor pentamer 2 cation channel Ion Permeation through the Acetylcholine Receptor electrostatic external intermediate internal M2 single channel conductance Gating of the Acetylcholine Receptor ACh binding energy induces a conformational change - integral ion channel, gated by ligand binding- multiple subunits- fast synaptic transmission Acetylcholine...
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This note was uploaded on 02/15/2011 for the course BIO 328 taught by Professor Cabot during the Fall '07 term at SUNY Stony Brook.

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lecture5 - Synaptic Transmission 1 Structure and Function...

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