MMI188 Lec 8

MMI188 Lec 8 - B Cell Development Chapter 6 Joseph M....

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B Cell Development Chapter 6 Joseph M. Tuscano, M.D. Associate Professor of Medicine
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Overview • B cell development • Heavy and Light chain rearrangement • Clonal deletion • Receptor editing • Affinity maturation • Terminal maturation • Translation of this knowledge into a better understanding and treatment of human disease
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The Immune System Innate (natural) Immunity Acquired (adaptive) Immunity
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Figure 4-1 part 1 of 2
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Figure 4-1 part 2 of 2
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Figure 4-2
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Figure 4-3 part 1 of 2
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Figure 4-3 part 2 of 2
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Figure 4-4
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Figure 4-5
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Figure 4-7 *Dependent upon RAG-1/2 expression
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Figure 4-8
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Figure 4-9 part 1 of 3
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Figure 4-9 part 2 of 3
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Figure 4-9 part 3 of 3
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Figure 4-9
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Figure 4-10 part 1 of 3
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Figure 4-10 part 2 of 3
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Figure 4-10 part 3 of 3
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Figure 4-10
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Figure 4-11
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Figure 4-12 part 1 of 2 CD5+
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Figure 4-12 part 2 of 2 CD5+
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Fine Tuning of the B Cell Repertoire
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Figure 4-13
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Figure 4-14 part 1 of 2
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Figure 4-14 part 2 of 2
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Figure 4-16
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MMI188 Lec 8 - B Cell Development Chapter 6 Joseph M....

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