PHGY 212 slides NFB 2010

PHGY 212 slides NFB 2010 - Physiology PHGY 212D Immunology...

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Physiology PHGY 212D Immunology Laboratory Nov 22 nd to Dec 3 rd Technicians – Domnica Marghescu and Rosemarie Siegrist-Johnstone Lab Teaching Assistant – Christine Hantouche Laboratory coordinator – Nicole Bernard, Ph.D.
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Overview Background The immune system and cells Immunoglobulin molecule Structure Function Lab experiments Hemagglutination Complement mediated lysis Enzyme linked immunosorbent assay (ELISA)
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The Immune System Organization Primary lymphoid organs Thymus Bone marrow Function To produce a large repertoire of cells able to recognize and respond To eliminate self-reactive cells
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The Immune System (con’t) Secondary Lymphoid organs Spleen, Lymph Nodes, Mucosal Associated Lymphoid Tissue (MALT), Bronchial Associated Lymphoid Tissue (BALT), Tonsils, Adenoids, Peyer’s patches gut associated lymphoid tissue (GALT). Function Provide an environment for Proliferation Maturation Filter and trap antigen Provide and environment for cell-cell interaction and cytokine cell interaction
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B cells: antigen recognition to antibody secretion
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Fc region
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Immunoglobulin (Ig) Fc region important in Complement binding Binds FC receptors on NK cells, macrophages, dendritic cells, neutrophils Antibody dependent cellular cytotoxicity (NK cells) Opsonization Ig class
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Immunoglobulin Antigen binding region Light chain and heavy chain variable regions contribute to antigen binding. Varies from one Ig molecule to another
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The course of a typical antibody response
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Active Immunity The first exposure to antigen results usually in low levels of antibody produced 5 to 7 days after immunization. Subsequent exposures result in high levels of antibody produced sooner after the second contact. Mechanism is the preexistence of memory cells formed
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PHGY 212 slides NFB 2010 - Physiology PHGY 212D Immunology...

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