aging theories

aging theories - 9/22/10
 Aging
Theories
 • 

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Unformatted text preview: 9/22/10
 Aging
Theories
 •  Diminished
capacity
to
regulate
the
internal
environment,
resulting
in
a
 reduced
probability
of
survival.
 Aging
Theories
 •  Aging
occurs
because
of
of
physical
and
biological
changes
in
the
human
 body.
 •  How
people
age
depends
on

 –  Genetics,
environment
and
lifestyle
 Aging
Theories
 •  Divided
into
genetic
and
nongenetic

  
Genetic
Theories
  Aging
is
programmed
into
the
cell
nucleus.
 Genetic
Theories
 •  Programming
Theory
 –  Aging
is
a
cellular
phenomenon;
cellular
clock.

We
 are
programmed
to
self‐destruct.

Also
called
 Death
Gene
 –  Hayflick
limit
theory
 •  The
number
of
cell
replication,
population
doubling
 potential,
possible
in
the
life‐span
is
approximately
50.
  
Nongenetic
Theories
  Changes
occur
because
of
influence
outside
the
cell
 nucleus.
 Genetic
cleansing
theory
 •  Clean
the
earth
of
old
genes.
 •  But
why
do
humans
live
so
long?
 –  “Grandmothering ”
theory
 Nongenetic
Theories
 •  “Views
aging
as
wear
and
tear
on
the
body.”
 •  But:

People
who
exercise
don’t
wear
out
 faster.

This
raises
the
question
between
 wearing
out
v
rusting
out.
 1
 9/22/10
 Nongenetic
Theories
 •  Dr.
August
Weismann,
1882.

 –  the
body
and
its
cells
were
damaged
by
overuse
 and
abuse.
The
organs
are
worn
down

 •  by
toxins
in
our
diet
and
in
the
environment;

 •  by
the
excessive
consumption
of
fat,
sugar,
caffeine,
 alcohol
and
nicotine;

 •  by
the
ultra‐violet
rays
 Nongenetic
Theories
 •  Other
nongenetic
theories
of
aging
 •  Free
radicals
 •  Diminished
immune
system
 •  Cellular
mutation
 •  Hormonal
theories.
 Free
radicals
 •  Disrupt
cell
metabolism
 •  Attack
collagen

 •  May
lead
to
cancer
and
death
 •  Helped
with
antioxidants
 Diminished
immune
system
 •  Less
production
of
antibodies
 •  Also
autoimmune
issues.
 Hormonal
theories 

 •  Lower
hormonal
production
from
 hypothalamus
 •  Body
less
able
to
regulate
internal
environment.


 Death
hormone
 •  DECO
(decreasing
oxygen
consumption
 hormone)

 •  Cardiovascular
and
immune
system
restored
 to
younger
levels
without
this
hormone.
 2
 9/22/10
 Fountain
of
youth
 •  Telomere
therapy
 –  Tiny
protective
areas
at
the
tip
of
chromosomes
 –  Get
shorter
each
time
cell
divides
 –  Make
the
telomeres
longer
 Antioxidants
 •  Neutralize
free
radicals
 •  May
be
possible
to
insert
human
genes
that
 produce
antioxidant
enzymes
 Bionic
solution
 •  Just
replace
worn
out
organs
 •  Possibly
clone
organs
to
reduce
rejection.
 Restricting
calories
 •  Starved
lab
rats
live
30%
longer
than
well
fed
 rats.
 •  Fewer
free
radicals.
 3
 ...
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