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Example%20Grant%20Assignment%20#3 - Name Grant Assignment#3...

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Name Grant Assignment #3: Background and Significance Due: October 30, 2008 The effect of nonsteroidal anti- inflammatory drugs (NSAIDs) on the development of exercise-associated hyponatremia in athletes.
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Hyponatremia is a condition in which an individual’s plasma sodium concentration is too low, with values < 135 mmol sodium/liter of plasma [1] . This grant will focus specifically on exercise-associated hyponatremia (EAH) which occurs particularly during prolonged endurance exercise. Athletes who are experiencing early stages of EAH may show signs of bloating, nausea, vomiting, and headache. As the severity of the condition progresses neurological symptoms such as confusion, disorientation, seizures, and altered mental status may take place as a result of cerebral edema (brain swelling). If symptoms are left to persist, more severe complications such as hospitalization and even death can occur. [2] Since the early 1980’s, statistics have shown an increasing incidence of EAH in the United States. The main reason behind this trend is believed to be an overall change in the hydration practices of endurance athletes over the years. [3] Excessive fluid consumption during exercise may reflect a conditioned behavior that has occurred due to recommendations to drink fluid during exercise to avoid
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